Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke

Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke

Blog Article

Abstract As global temperatures rise, heat-related chronic health disorders are predicted to become more prevalent.We tested whether a single exposure to acute heat illness, using a preclinical mouse model of exertional heat stroke (EHS), can induce late-emerging health disorders that progress into chronic disease.Following EHS, mice were followed for 3 months; after two weeks of recovery, half were placed on a teal horse blanket Western diet to determine if previous EHS exposure amplifies the negative consequences of an atherogenic diet.When compared to sham exercise controls, EHS-exposed mice exhibit accelerated diet-induced obesity, develop low level cardiac hypertrophy, develop accelerated diet-induced liver steatosis, severe hypoproteinemia and a loss of metabolic flexibility in the myocardium.The latter is characterized by a shift towards predominant glucose metabolism and glycolysis.

These results demonstrate that a single exposure canine spectra kc 3 intranasal single dose to severe exertional heat illness can induce long-lasting and unexpected health consequences in mammals and increased vulnerability to secondary metabolic stressors.